The Buddha taught that there are five preconditions necessary for the development of meditation practice in seclusion—good friends, virtue and restraint, engaging in talk on the Dhamma, wise effort, wisdom. These preconditions, presented in the Meghiya Sutta, are developed progressively and support one another, with wisdom as the crowning jewel and chief. This talk explores the importance of wisdom for revealing the impermanent nature of all things. With the clarity of wisdom we discern the arising and passing of phenomena. This insight into impermanence undercuts habitual delusions that perpetuate blindly grasping and clinging transient things. Wisdom is important at all stages of the path. At the beginning of our practice, we need wisdom to discern the right direction, clarify our purpose and learn skillful methods; we need wisdom in the midst of the practice to make the many adjustments that sustain us on this path; and the path culminates in the wisdom that leads to release. With wisdom, we will see the changing nature of all things, and understand how we construct our perception of reality, discern the four noble truths of suffering, and recognize how we can realize the end of suffering.