The Buddha famously said, “I have dukkha and the end of dukkha.” Yet it can be confusing to know what the Buddha might have meant. One reason for the confusion is that there are multiple accounts of dukkha in the discourses; we explore four of them, finding that, for the first three, it doesn't make sense to speak of the "the end of dukkha." Only for the fourth sense of dukkha, which we find both in the teaching of the Two Arrows (or Darts) and in the teaching of Dependent Origination does "the end of dukkha" make sense. On this basis, we then explore the nature of dukkha, interpreted especially as reactivity, which we find in two forms--grasping and pushing away. We lastly explore eight core ways of practicing with dukkha.